Last reviewed: 2026-04-18 by Jake Terry, FFL07/SOT3, NRA-certified firearms instructor.
Hodgdon H380 powder stands as one of the most reliable spherical propellants for centerfire varmint cartridges, built around a burn rate that excels in medium-capacity cases pushing light-to-medium projectiles. Developed initially for the 22-250 Remington, H380 smokeless powder has earned a reputation among handloaders for metering consistency, temperature stability, and the velocity needed to flatten trajectory on prairie dogs and coyotes at extended range.
Load Profile
H380’s spherical grain structure flows through powder measures with minimal bridging, making charge weights repeatable across long loading sessions. The burn rate sits between IMR 4064 and IMR 4350, positioning it for cartridges in the 22-250, 243 Winchester, 220 Swift, and 257 Roberts family. Handloaders report clean combustion and copper fouling levels consistent with other extruded and ball powders in this velocity class.

The Numbers
| Spec | Value |
|---|---|
| Shipping Weight | 1.155 Pounds – 8.370 Pounds |
| DOT-Regulated | Yes |
| HazMat Product | Yes |
Hodgdon publishes load data for H380 across a wide range of varmint and medium-game cartridges. Start loads at the minimum charge weight listed in current reloading manuals and work up in 0.5-grain increments, watching for pressure signs. All gun powder shipments require HazMat fees and adult signature upon delivery.
Where It Shines
H380 fits handloaders running bolt-action varmint rifles in 22-250 and 243 Winchester, where consistent velocity and lot-to-lot uniformity matter for wind-reading at 300+ yards. The powder meters well in progressive presses and single-stage setups alike, reducing the need for trickler adjustments. Shooters report best results with bullets in the 50-70 grain range for 22-caliber and 80-100 grains for 6mm applications.
Safe Handling & Compliance
Smokeless powder is regulated as a Class 1.3C explosive and ships via HazMat-certified carriers only. Federal law does not restrict powder sales by age, but state and local ordinances may impose storage limits, permitting requirements, or quantity caps — verify current regulations in your jurisdiction before ordering.
- Store powder in original containers in a cool, dry location away from heat sources, open flame, and electrical panels.
- Never mix powders of different types, brands, or lot numbers — even small contamination can cause dangerous pressure excursions.
- Always reference current published load data from Hodgdon or other reputable sources; do not exceed maximum charges or substitute powders without verifying burn rates and pressure curves.





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